The collision happened shortly after 11am on Friday on the A606, near the Leesthorpe turning, and involved a grey Volvo XC40 and a white Vauxhall Vivaro van and led to the road being closed until late evening.
Police say three people in the Volvo – a man and woman in their 70s and a man in his 60s – were taken to hospital to be treated for ‘significant injuries’.
No arrests were made and enquiries into the collision are continuing.
PC Liam Street, from the Roads Policing Unit, said: “I’d like to speak to any motorists in the area who have a dashcam in their vehicle but who have not yet contacted police.
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“I’d also like to speak to anyone who witnessed the collision or saw either vehicle beforehand. Any information you have could help my investigation.”