Melton made it nine straight league wins against local rivals Cottesmore to guarantee they will head into the new year top of the tree.
Cottesmore named former Melton players Rob Grant and Simon Hill in their starting line-up which added extra spice to the match.
But the visitors started professionally on an excellent playing surface, moving the ball with confidence and pace as they pressed Amateurs from the first whistle.
Ash Palfreyman tested the keeper early on, but it was Bishop who opened the scoring on 15 minutes, lifting the ball over the keeper from just outside the six-yard box to finish off a good move.
Melton continued to control the game and Palfreyman added to the lead when he powerfully headed in.
Kieran Clayton was now dictating midfield and winning every header, but Melton could not extend their lead as Palfreyman and Aaron Black wasted some excellent chances.
Melton started the second half at a good pace and soon went 3-0 up when Jack Baker fired in from the edge of the area after the ball fell kindly onto his left foot.
Mowbray again looked solid at the back with Leon Fray having another good game in the heart of defence.
Clayton fittingly finished off the scoring when he tapped in the fourth from close range, capping another good display as Melton moved four points clear.
Man-of-the-match, sponsored by Williamson Air Conditioning, was Kieran Clayton.
Melton: Cragg, Levi Fray, Aidan Black (Palfreyman), Cooper, Leon Fray, Mann (c), Baker, Clayton, Aaron Black (Love), Bishop (Stapleton), Palfreyman.