Holwell came away pleased with their afternoon’s work after gaining their first league win at Anstey since May 2010.
Simon Daws’ side came into the match with recent fixtures disrupted by the weather and faced a match-fit Anstey side who were looking to avenge defeats in the FA Vase and League Cup.
Denigan was missing because of work commitments, Rose started a two-match suspension, while keeper Stainsby saw out the remaining match of his suspension. Randall was injured, and Smith was also unavailable so in came Hallam and Keast.
Holwell started brightly and could have been three goals to the good within 15 minutes.
Wells flashed a header over in the opening two minutes before Mooney shot wide. Wells then had a chance from six yards, but failed to connect with his header, and Hibbitt fired a shot over the bar from distance.
Holwell finally made the breakthrough their early pressure deserved when Foster played a one-two with Keast, making his first start of the season, before shooting across goal into the net.
Five minutes later Holwell doubled their lead, when Keast’s chip put Wells through to flick a header over the helpless keeper.
Mooney twice went close, while Stannard had a shot blocked as the visitors continued to threaten.
But Anstey also looked dangerous on the break with only good last-ditch defending protecting Holwell’s goal.
The visitors came out after half-time looking to kill off the game with a third, but were pinned deep in their own half in a role reversal of the first half.
Holwell threatened on the break but their passing was now lacking in quality. Mooney fired Holwell’s best chance over before Wells followed suit.
At the other end Holwell were beginning to ride their luck, and only more last-ditch defending and wayward finishing denied Anstey a route back into the match.
Anstey finally breached Holwell’s rearguard with five minutes left when Hartopp burst through and slotted into the empty net.
As Cropston Road braced itself for a grandstand finish, Daws replaced Stannard with Calver and moments later the sub sealed the points, turning sharply in the box to fire into the top corner from another Keast assist.
Holwell saw out injury time without further scares to move up to 12th, only three points adrift of eighth place with games in hand.
On Saturday, Holwell take on Aylestone Park who are down in 19th, but buoyed by a good 2-2 draw at top seven side Barrow on Saturday.