The school, which has 114 pupils aged between five and 19, has been visited by health workers for the first round of injections.
Parents had to decide for themselves if they were happy for their child to have the vaccination.
Staff and children
at special schools across the county have been offered the vaccinations as children with special needs are more at risk of developing serious complications from swine flu.
Kate Bell, headteacher of Birch Wood School, said: "The school is just acting as a venue to give injections. It is up to parents to say if they want their children to have the injection or not.
"The injections have also been offered to staff because we give personal care to pupils.
"Individual members of staff must also decide for themselves."
"It is the same for the adults. Some people are concerned that the vaccine has not been tested long enough and others wondering if they have already had swine flu, should they have the injection. People want all the information so they can make an informed choice."
Experts have been on hand to talk to parents concerned about the effect of the anti-viral because of other medication their children are taking for what can be complex medical needs.
More than 4,500 frontline health and social care staff in Leicestershire - who are both at increased risk of catching and passing on the swine flu virus - have taken advantage of the jab.
About 100,000 doses of the vaccine have now arrived in Leicestershire and it is hoped a further 100,000 doses will be here before Christmas.
Health officials say vulnerable groups, including children under five, will now be offered the vaccine and will be contacted by their GP in due course.